Chapter 31. Eosinophilic Lung Diseases

Stephanie M Levine, MD, FCCP
DOI: 10.1378/pulm.26.31
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  • Review the classification of the eosinophilic lung diseases.

  • Describe the structure and function of the eosinophil.

  • Review the clinical features of allergic bronchopulmonary aspergillosis.

  • Discuss the clinical features of the idiopathic acute and chronic eosinophilic pneumonia.

  • Discuss the clinical features of Churg-Strauss syndrome and hypereosinophilic syndrome.


The eosinophilic lung diseases are a heterogeneous group of disorders characterized by an increased number of eosinophils in one or more of the compartments of the lung and, in many of these disease entities, the peripheral blood. These disorders may be associated with known causative factors, may be idiopathic, or may be associated with other systemic diseases. This chapter will review the pulmonary eosinophilic disorders thought to be due to secondary etiologies, including allergic bronchopulmonary aspergillosis, parasitic-related simple pulmonary eosinophilia, tropical pulmonary eosinophilia, and drug-induced pulmonary eosinophilia. The chapter will also review the idiopathic disorders, both pulmonary-limited acute eosinophilic pneumonia and chronic eosinophilic pneumonia, and those associated with systemic disease—Churg-Strauss syndrome and hypereosinophilic syndrome. For most of these disease processes, the etiology; pathogenesis; clinical, laboratory, radiographic, and pulmonary function findings; diagnostic criteria; and treatment will be discussed.


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