Chapter 32. Tuberculosis and Other Mycobacterial Diseases

David Ashkin, MD
DOI: 10.1378/pulm.26.32
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TB is still a leading cause of death worldwide despite the availability of an effective medical cure. Fueled by the worldwide HIV epidemic and the development of drug-resistant strains, the control of TB is still a major public health issue. This chapter will review the epidemiology of TB in the United States as well as the world. Guidelines for the diagnosis of latent TB infection, including new tools such as interferon release assays interferon release assays, will be reviewed, as well as the currently recommended treatment options. Guidelines for the diagnosis of active TB disease, including molecular diagnostics, and treatment options for active TB disease, including for individuals with drug-resistant strains, will also be addressed. Infection control issues concerning TB will also be discussed. The epidemiology, diagnosis, and treatment of patients with disease caused by nontuberculous mycobacteria, which is more prevalent in the United States than TB, will also be reviewed.

  • Become familiar with the epidemiology of TB.

  • Review the pathogenesis and clinical presentation of TB.

  • Address issues concerning the prevention of TB, including the diagnosis and treatment of TB infection.

  • Review issues concerning the diagnosis and treatment of TB disease.

  • Outline pertinent topics concerning mycobacteria other than TB (eg, Mycobacterium avium complex and Mycobacterium kansasii).


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